Hyaluronic Acid vs Sodium Hyaluronate: Unveiling the Moisturizer Effects

Time : 2025.03.14 Page View : 462 Author : Alice

What Is Hyaluronic Acid?

hyaluronic acid, an acidic mucopolysaccharide and a glycosaminoglycan composed of disaccharide units of D-glucuronic acid and N-acetylglucosamine, has the molecular formula (C14H21NO11). It was first extracted from the vitreous humor of bovine eyes by Karl Meyer, a professor of ophthalmology at Columbia University in the United States, in 1934. Due to its unique molecular structure and distinctive physicochemical properties, hyaluronic acid plays a multitude of vital physiological roles within the body. These functions include lubricating joints, regulating the permeability of blood vessel walls, and promoting wound healing.

What Is Sodium Hyaluronate?

Sodium hyaluronate is the sodium salt form of hyaluronic acid, a natural polysaccharide that can be extracted from cockscombs or fermented by lactic acid cocci. It is white or off-white granules or powder, odorless, highly viscoelastic, plastic, permeable, and more stable in appearance.

The Difference Between Hyaluronic Acid and Sodium Hyaluronate

There are significant differences between hyaluronic acid and sodium hyaluronate in terms of chemical structure, stability, functions and efficacy, usage methods and adverse reactions. Hyaluronic acid occupies an important position in the medical field with its powerful moisturizing and repairing capabilities; while sodium hyaluronate is widely used in cosmetics and medical injections because of its smaller molecule, stronger permeability and stability.

Both hyaluronic acid and sodium hyaluronate have good moisturizing effects, but sodium hyaluronate has smaller molecules and can penetrate deeper into the skin to achieve deeper hydration. Hyaluronic acid acts more on the surface of the skin, locking in moisture through its powerful water absorption capacity.

Both provide nutrients to the skin and promote skin repair. Due to its small molecule and strong permeability, sodium hyaluronate can penetrate deep into skin cells more effectively and promote cell metabolism and repair. Hyaluronic acid improves the overall condition of the skin mainly through its water-retaining effect.

Sodium hyaluronate is often used in combination with collagen peptide, vitamin C, vitamin E and other raw materials to improve skin moisture. In products that enhance bone density, sodium hyaluronate is often used in combination with chondroitin sulfate, glucosamine hydrochloride, calcium carbonate and other raw materials to enhance bone density. In cosmetics, sodium hyaluronate can be used in combination with ingredients such as γ-aminobutyric acid, tetrahydropyrimidines, hydroxypropyl-β-cyclodextrin, α-arbutin, retinal, antimicrobial peptides, etc. to enhance moisturizing, anti-wrinkle, sun protection and after-sun repair effects.

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